Periorbital wrinkles treatment using collagen induction therapy

Introduction: Periorbital wrinkles are very common and permanent cutaneous folds that develop on the periocular area. The treatment for wrinkles varies with the degree of severity. A relatively new treatment, called collagen induction therapy (CIT), seems to be appropriate for the treatment of periorbital wrinkles. Objective: To confi rm the usefulness of CIT in periorbital wrinkles treatment. Patients and methods: In total, 20 patients (12 females, 8 males; between 50-65 years of age) with periorbital wrinkles were included. Each patient was treated with a specifi c tool in two sessions. Using digital cameras, photos of all patients were taken to evaluate wrinkles’ depth, and silicone rubber was used to make a microrelief impression of the wrinkles. The photographic data were analysed by using the sign test statistic (α < 0.05). Skin layer data were analysed by computerized image analysis. Results: Analysis of the patient photographs, supported by the sign test, and the degree of irregularity of the surface microrelief, supported by Fast Fourier Transform and by wrinkle’s image processing, showed that, after only two sessions, the wrinkles’ severity grade in most patients was greatly reduced. Conclusion: The present study suggests that CIT can be a suitable technique to improve periorbital wrinkles.